Found most often in Acts and Second Corinthians, but also used in several other New Testament books (twenty-four times total), the Greek noun “epistole” meant “epistle,” “written message,” “letter.”

“The NT epistles are occasional letters (called forth by specific occasions or situations), and this too supplies imagery, motifs, and content for the epistles.  Only rarely (most notably in the epistle to the *Romans) do we find systematic treatises on a theological topic.  The general format is to take up questions or points of controversy that are known to exist in the life of the church or individual who is addressed.  It is a fair inference that the recipient(s) of a letter already knew the author’s views on the central issues of the Christian faith.  The author takes these for granted and directs his remarks instead to more specific questions, doubts, errors or problems.  What emerges, therefore, is an ever-expanding picture of the early church in various regions of the Graeco-Roman world” (Dictionary of Biblical Imagery, Ryken, Wilhoit, Longman III, p. 243).
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We read about uninspired letters in Acts 9:2; 23:25, 33.  Paul said he wrote “letters” (1 Cor. 16:3) and these were regarded as powerful (2 Cor. 10:10).  “All” the recipients were to hear the contents of inspired letters (1 Thess. 5:27).  At least some of the inspired letters were shared with other congregations (Col. 4:16).  Failing to obey what was in an inspired letter merited punishment (2 Thess. 3:14).  Paul authenticated his letters (2 Thess. 3:17).  Some of what Paul wrote was difficult, even for the original readers, to grasp (2 Pet. 3:16).